Clinical studies and trials

The Walton Centre currently has over 75 studies open to recruitment at our site. These cover many different neurological and surgical conditions, including Parkinson’s disease, Huntington’s disease, and many neurological disorders.

Please find below a list of larger studies currently taking place at The Walton Centre. Please note that there are many other trials which are not listed on this page that may be suitable for you. For further information in getting involved in clinical research, please see our page on Getting involved in research

TONiC – Trajectories of Outcome in Neurological Conditions


TONiC is a national study examining the factors that influence quality of life in patients with neurological conditions. It is one of the largest studies on quality of life in neurological conditions ever performed within the UK. 

It is hoped that TONiC will have a significant and positive impact on the lives of all patients that suffer from neurological diseases regardless of symptoms, stage of illness, age or social status.

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Enroll-HD is a worldwide study for Huntington’s disease families. It will monitor how the disease appears and changes over time in different people, and is open to people who either have HD or are at-risk. Knowing how the disease unfolds will make it much easier to determine what drugs and treatments will help to slow down or stop these changes.

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The BRAIN MATRIX research trial is a first-of-its-kind clinical trial, aiming to collect a comprehensive data set of patients to help provide a better diagnosis of their disease. It aims to improve overall quality of life, as well as refining and improving surgery based on its findings.

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PROGRESS – Atogepant in Chronic Migraine

PROGRESS is one of a number of drug trials taking place at The Walton Centre, studying the effects of a drug called Atogepant on preventing chronic migraine. Approximately 30 people will be recruited into the study within the UK. For further information please contact the team at  


Developing a preconception care pathway for women with epilepsy

This is a national study to develop a preconception care pathway for women with epilepsy in the UK. We hope this study will have an impact to improve the lives of women with epilepsy planning pregnancy.

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Page last updated: 20 October 2022